Abstract |
A double-blind, controlled trial was performed to assess the effect of a short intraoperative course of Cefoxitin, a new broad spectrum cephamycin antibiotic, on the incidence of septic complications following elective colonic and rectal surgery. In addition to a two-day preoperative bowel preparation, patients entered in the study received a short course of either Cefoxitin (three 2g intravenous bolus doses at two-hour intervals, the first before skin incision) or a matching placebo. Thirty-two patients received Cefoxitin and 33 patients received the placebo. Postoperative abdominal wound infections developed in one (3%) of the Cefoxitin-treated patients and nine (27%) of the placebo-treated patients. This difference is statistically significant (p = 0.01). Septic complications remote from the abdominal wound, e.g. intra-abdominal abscesses, occurred in both Cefoxitin-treated and placebo-treated patients, but numbers were too small for meaningful analysis. The study shows that even a very short peroperative course of Cefoxitin is highly effective in reducing postoperative abdominal wound infections after elective colorectal surgery.
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Authors | C E Hoffmann, P J McDonald, J M Watts |
Journal | Annals of surgery
(Ann Surg)
Vol. 193
Issue 3
Pg. 353-6
(Mar 1981)
ISSN: 0003-4932 [Print] United States |
PMID | 7011223
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Bacterial Infections
(prevention & control)
- Cefoxitin
(therapeutic use)
- Clinical Trials as Topic
- Colon
(surgery)
- Double-Blind Method
- Female
- Humans
- Intraoperative Period
- Male
- Middle Aged
- Postoperative Complications
(prevention & control)
- Premedication
- Rectum
(surgery)
- Surgical Wound Infection
(prevention & control)
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