Double-blind trial of trimipramine in the treatment of duodenal ulcer.

Twenty-three patients with chronic duodenal ulcer were allocated randomly to receive either trimipramine 25 mg or placebo, as a single night-time dose, for six weeks. Ulcer healing was determined by endoscopy. The ulcer healed in two of 10 patients receiving trimipramine and in seven of 13 patients receiving placebo. Trimipramine in this dosage does not assist ulcer healing.
AuthorsG J Don, D J Shearman, R Hecker
JournalThe Medical journal of Australia (Med J Aust) Vol. 2 Issue 10 Pg. 567-8 (Nov 15 1980) ISSN: 0025-729X [Print] AUSTRALIA
PMID7007837 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Dibenzazepines
  • Placebos
  • Trimipramine
  • Clinical Trials as Topic
  • Dibenzazepines (therapeutic use)
  • Double-Blind Method
  • Duodenal Ulcer (drug therapy)
  • Endoscopy
  • Humans
  • Placebos
  • Random Allocation
  • Trimipramine (administration & dosage, therapeutic use)

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