[Quantitative immunoenzyme method of analyzing embryonal prealbumin (EPA-1) in biological fluids].

Abstract

A quantitative immunoenzymatic method (ELISA) has been developed for detection of embryonic prealbumin (EPA-1). This method allows EPA-1 to be detected in human serum in an amount of 4 to 100 ng/ml. The high levels of EPA-1 (over 4 ng/ml) were observed in all cases (27 patients) of tumors of connective tissues, in 50 of 51 in brain tumors, in 39 of 341 in gastrointestinal tract tumors, in 4 of 13 in breast tumors, and in 21 of 51 tumors of the respiratory tract. The levels of EPA-1 in donors and pregnant woman sera normally did not exceed 4 ng/ml. However, about 3% of the samples of these sera had the levels of EPA-1 from 4 to 12 ng/ml.

• Authors: V V Kalashnikov, S G Voloshchuk, Iu S Tatarinov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 90 Issue 11 Pg. 628-30 (Nov 1980) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Kolichestvennyĭ immunofermentnyĭ metod opredeleniia émbrional'nogo preal'bumina (EPA-1) v biologicheskikh zhidkostiakh.
• PMID: 7004529 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Prealbumin
• Serum Albumin

Topics

• Bone Neoplasms (blood)
• Brain Neoplasms (blood)
• Cartilage Diseases (blood)
• Female
• Gastrointestinal Neoplasms (blood)
• Humans
• Immunoenzyme Techniques
• Male
• Neoplasms (blood)
• Prealbumin (analysis)
• Pregnancy
• Respiratory Tract Neoplasms (blood)
• Serum Albumin (analysis)
• Soft Tissue Neoplasms (blood)