HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Controlled trial of cimetidine in reflux esophagitis.

Abstract
In an eight-week double-blind trial, the effectiveness of cimetidine (1.6 g/day) was compared to placebo in 34 patients with symptomatic esophagitis confirmed by endoscopy with biopsies and/or by acid infusion test. Patients treated with cimetidine had significantly less symptomatic days during the first six weeks and less symptomatic nights during the first two weeks, and they consumed less antacids during the whole trial period. Endoscopic evaluation of 17 patients on cimetidine and of 15 patients on placebo did not show any significant difference in severity and extent of esophageal lesions after eight weeks, but histological assessment of 16 patients on cimetidine and 13 patients on placebo showed a significant improvement after eight weeks of cimetidine (P < 0.025). These results show that cimetidine has a rapid effect on symptoms of reflux esophagitis and that, in some cases, it may reduce the esophageal lesions after eight weeks.
AuthorsR Fiasse, C Hanin, A Lepot, C Descamps, F Lamy, C Dive
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 25 Issue 10 Pg. 750-5 (Oct 1980) ISSN: 0163-2116 [Print] United States
PMID7000475 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Alginates
  • Antacids
  • Guanidines
  • Placebos
  • Cimetidine
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Alginates (administration & dosage)
  • Antacids (administration & dosage)
  • Cimetidine (administration & dosage, therapeutic use)
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Esophagitis, Peptic (drug therapy)
  • Female
  • Follow-Up Studies
  • Guanidines (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Placebos
  • Research Design
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: