Abstract |
Forty-two patients with previously untreated T3/4 N1-4 MO/1 prostatic adenocarcinoma were treated with either cyproterone acetate (n = 21; 300 mg intramuscularly per week) or oestradiol undecylate (n = 21; 100 mg intramuscularly per month) after extensive staging which included open skeletal biopsy and pelvic lymphadenectomy in some cases. Subjective and objective parameters as well as signs of drug toxicity were recorded regularly. Evaluation after 6 months showed cyproterone acetate to be more effective in the following respects: (1) the significantly different castration effect as judged by plasma testosterone, (2) the objective voiding pattern and tumour response, with regression of palpable and histologically evaluable local tumour in 16 of 21 patients, and (3) side effects and untoward reactions. Thus cyproterone acetate is suggested as a valuable alternative in the treatment of advanced prostatic cancer.
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Authors | G H Jacobi, J E Altwein, K H Kurth, R Basting, R Hohenfellner |
Journal | British journal of urology
(Br J Urol)
Vol. 52
Issue 3
Pg. 208-15
(Jun 1980)
ISSN: 0007-1331 [Print] England |
PMID | 7000222
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adenocarcinoma
(drug therapy, pathology)
- Aged
- Clinical Trials as Topic
- Cyproterone
(adverse effects, therapeutic use)
- Estradiol
(adverse effects, therapeutic use)
- Humans
- Male
- Middle Aged
- Prostatic Neoplasms
(drug therapy, pathology)
- Random Allocation
- Time Factors
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