[Experimental studies of the duration of hexobarbital sleep and of the level of cytochrom P-450 and B5 in the microsomal fraction of rat liver after propoxur treatment].

Abstract

Male sex-mature rats of the Wistar Strain with weight of 180--20 gm were treated per os daily for a period of 60 days with 1/10 of LD50 of Propoxur (10 mg of body weight per day of 2-isopropoxiphenyl-N-methylcarbamate). There was induction of cytochromosomal P-450 and B5 in the end of the first week after the intoxication was induced and shortening of hexobarbital sleep during the same period as well as on the thirtieth day since the onset of the experiment.

• Authors: P Nenov, F Ribarova
• Journal: Eksperimentalna meditsina i morfologiia (Eksp Med Morfol) Vol. 17 Issue 3 Pg. 118-21 ( 1978) ISSN: 0367-0643 [Print] Bulgaria
• Vernacular Title: Eksperimentalni prouchvaniia vurkhu produlzhitelnostta na kheksobarbitalovata markoza i nivoto na tsitokhromite P-450 i B5 v mikrozomnata fraktsiia na cherniia drob na plukhove sled tretirane s propoksur.
• PMID: 699864 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cytochromes
• Cytochrome P-450 Enzyme System
• Hexobarbital
• Propoxur

Topics

• Animals
• Cytochrome P-450 Enzyme System (metabolism)
• Cytochromes (metabolism)
• Drug Interactions
• Hexobarbital (pharmacology)
• Male
• Microsomes, Liver (drug effects)
• Propoxur (toxicity)
• Rats
• Sleep (drug effects)
• Time Factors