Antagonists of morphine-induced respiratory depression. A study in postoperative patients.

Abstract

This double blind study showed the effect of four drugs, levallorphan, naloxone, doxapram and amiphenazole, an opiate-induced analgesia and respiratory depression. Satisfactory analgesia was induced by administration of morphine intravenously in a dose of up to 0.33 mg/kg; such a dose, however, produced significant depression of respiration. Administration of levallorphan, naloxone, and amiphenazole produced reversal of respiratory depression and analgesia. Doxapram reversed the respiratory depression but did not alter analgesia.

• Authors: R L Gairola, P K Gupta, K Pandley
• Journal: Anaesthesia (Anaesthesia) Vol. 35 Issue 1 Pg. 17-21 (Jan 1980) ISSN: 0003-2409 [Print] England
• PMID: 6994518 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Narcotic Antagonists
• Thiazoles
• Levallorphan
• Naloxone
• Morphine
• amiphenazole
• Doxapram

Topics

• Adult
• Clinical Trials as Topic
• Double-Blind Method
• Doxapram (therapeutic use)
• Humans
• Levallorphan (therapeutic use)
• Middle Aged
• Morphine (adverse effects, antagonists & inhibitors, therapeutic use)
• Naloxone (therapeutic use)
• Narcotic Antagonists (therapeutic use)
• Pain, Postoperative (drug therapy)
• Random Allocation
• Respiratory Insufficiency (chemically induced, drug therapy)
• Thiazoles (therapeutic use)
• Time Factors