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[Effect on peripheral blood cells in children with acute leukemia during remission by intramuscular injected of arabinosyl-cytosine (author's transl)].

Abstract
Investigation was done in children with acute leukemia in complete hematological remission. It was tested whether out-patient treatment by intramuscular administration of arabinosylcytosine (Ara-C) may obviate the continuous intravenous Ara-C regimen. Every therapy cycle lasted 5 days. Changes in peripheral blood cell counts after 5 days of continuous intravenous. Ara-C infusion against 5 days of intramuscular Ara-C application given every 12 h were tested. 129 cycles of intramuscular application and 11 cycles of intravenous application were evaluated. Evaluation was done by the Friedmanntest. There was a significant decrease in blood cell counts after intramuscular Ara-C treatment. When administered intramuscularly during the first cycle Ara-C was effective for at least 3 weeks, whereas after repeated cycles the decline of blood cells was only demonstrable for 14 days. A comparison of the effect between intravenous and intramuscular routes revealed similar results. No local side effects were noted when Ara-C was given intramuscularly.
AuthorsR J Haas, M Helmig, E Prentl
JournalOnkologie (Onkologie) Vol. 3 Issue 2 Pg. 53-7 (Apr 1980) ISSN: 0378-584X [Print] Switzerland
Vernacular TitleEffektivität intramuskulär verabreichten Cytosin-Arabinosids bei der ambulanten Behandlung von Kindern mit akuter Leukämie in Remission.
PMID6994005 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cytarabine
Topics
  • Blood Cell Count
  • Blood Cells (drug effects)
  • Child
  • Cytarabine (therapeutic use)
  • Humans
  • Leukemia, Lymphoid (drug therapy)
  • Leukemia, Myeloid, Acute (drug therapy)

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