Abstract |
Investigation was done in children with acute leukemia in complete hematological remission. It was tested whether out-patient treatment by intramuscular administration of arabinosylcytosine ( Ara-C) may obviate the continuous intravenous Ara-C regimen. Every therapy cycle lasted 5 days. Changes in peripheral blood cell counts after 5 days of continuous intravenous. Ara-C infusion against 5 days of intramuscular Ara-C application given every 12 h were tested. 129 cycles of intramuscular application and 11 cycles of intravenous application were evaluated. Evaluation was done by the Friedmanntest. There was a significant decrease in blood cell counts after intramuscular Ara-C treatment. When administered intramuscularly during the first cycle Ara-C was effective for at least 3 weeks, whereas after repeated cycles the decline of blood cells was only demonstrable for 14 days. A comparison of the effect between intravenous and intramuscular routes revealed similar results. No local side effects were noted when Ara-C was given intramuscularly.
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Authors | R J Haas, M Helmig, E Prentl |
Journal | Onkologie
(Onkologie)
Vol. 3
Issue 2
Pg. 53-7
(Apr 1980)
ISSN: 0378-584X [Print] Switzerland |
Vernacular Title | Effektivität intramuskulär verabreichten Cytosin-Arabinosids bei der ambulanten Behandlung von Kindern mit akuter Leukämie in Remission. |
PMID | 6994005
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Blood Cell Count
- Blood Cells
(drug effects)
- Child
- Cytarabine
(therapeutic use)
- Humans
- Leukemia, Lymphoid
(drug therapy)
- Leukemia, Myeloid, Acute
(drug therapy)
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