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Danazole in the treatment of hereditary angioedema.

Abstract
Danazol is an effective agent for the prophylaxis of the recurrent attacks of mucocutaneous and visceral swelling which occur in patients with hereditary angioedema (HAE). Danazol apparently increases the synthesis of the inhibitor of the first component of complement which is partially deficient in these heterozygous individuals. The efficacy of danazol in this condition appears to be limited only by the occurrence of adverse effects.
AuthorsS W Hosea, M M Frank
JournalDrugs (Drugs) Vol. 19 Issue 5 Pg. 370-2 (May 1980) ISSN: 0012-6667 [Print] New Zealand
PMID6993183 (Publication Type: Journal Article, Review)
Chemical References
  • Pregnadienes
  • Danazol
Topics
  • Angioedema (drug therapy, genetics)
  • Danazol (adverse effects, therapeutic use)
  • Humans
  • Pregnadienes (therapeutic use)

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