Abstract |
In 10 patients with mycosis fungoides (MF) who were in clinical remission following local treatment with nitrogen mustard, cell-mediated immunity was investigated by means of tests for lymphocytes, forming rosettes in the peripheral blood, and the graft-vs-host reaction as well as intradermal skin tests. The effect of thymic humoral factor (THF) on T lymphocytes with impaired immunecompetence was also investigated. The results provided evidence of various kinds of damage to the immunologic system in most of the patients. Of the 10 patients, 4 had low percentages of T cells. Eight of the 10 had a graft-vs.-host reaction which was weak or negative, and in 4 of these, the administration of THF to the lymphocytes induced an improvement in immunoreactivity. These results together with other recently reported data indicate that the determination of cell-mediated immunity in patients with MF may be of prognostic importance. Those patients whose T lymphocytes respond to treatment with THF are probably the best candidates for immunotherapy.
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Authors | M David, B Shohat, N Trainin, E Feuerman |
Journal | Cancer
(Cancer)
Vol. 46
Issue 1
Pg. 41-4
(Jul 01 1980)
ISSN: 0008-543X [Print] United States |
PMID | 6992976
(Publication Type: Journal Article)
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Chemical References |
- Thymus Hormones
- Mechlorethamine
- Thymic Factor, Circulating
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Topics |
- Adult
- Aged
- Animals
- Female
- Humans
- Immunity, Cellular
- Immunocompetence
- Immunologic Techniques
- Male
- Mechlorethamine
(therapeutic use)
- Middle Aged
- Mycosis Fungoides
(drug therapy, immunology)
- Rats
- T-Lymphocytes
(immunology)
- Thymic Factor, Circulating
(pharmacology)
- Thymus Hormones
(pharmacology)
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