Further evaluation of the microhaemagglutination test to determine treponemal antibodies in CSF.

Abstract

The results of a microhaemagglutination test (MHA:TP) using diluted (MHA:TP-DCSF) and undiluted (MHA:TP-UCSF) samples of cerebrospinal fluid (CSF) from 1452 patients with syphilis, neurological, metabolic, or immunological disorders, and undetermined diagnoses to detect antitreponemal antibodies were compared with those of the Venereal Disease Research Laboratory (VDRL-CSF) test and the fluorescent treponemal antibody (FTA-CSF) test. Using undiluted samples of CSF the MHA:TP test gave more reactive results than with diluted samples. The MHA:TP-UCSF test was slightly more specific and sensitive than the FTA-CSF test. The use of undiluted CSF did not reduce the specificity of the MHA:TP test, as was shown by testing CSF samples from patients with diseases other than syphilis.

• Authors: S Kasatiya, A Birry
• Journal: The British journal of venereal diseases (Br J Vener Dis) Vol. 56 Issue 2 Pg. 77-80 (Apr 1980) ISSN: 0007-134X [Print] England
• PMID: 6992940 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Bacterial

Topics

• Antibodies, Bacterial (cerebrospinal fluid)
• Evaluation Studies as Topic
• Fluorescent Antibody Technique
• Hemagglutination Tests
• Humans
• Syphilis (cerebrospinal fluid)
• Treponema pallidum (immunology)