Abstract |
The synthetic biopolymer NED 137 is capable of stimulating an immune response to tumor antigen. This article compares the efficacy of NED 137 to bacille Calmette-Guerin, Corynebacterium parvum, pyran, levamisole, and Freund's complete adjuvant in a rat tumor model where adjuvant treatment is administered after excision of subcutaneous tumor implants. A single intraperitoneal injection of NED 137 at 30 mg/kg body weight prolonged survival beyond 60 days with no evidence of recurrent or metastatic disease, whereas with the other adjuvants, animals survived a mean of 30 to 40 days with 100% local recurrence and a 60% to 90% incidence of pulmonary metastases. Use of NED 137 resulted in a greater lysis of tumor cells compared to other adjuvants when assessed in an in vivo 51Cr release assay. A phase I clinical study of high-risk gastrointestinal cancer patients treated with NED 137 is reported at a median survival time of 23 weeks (103 patients). This group is compared to a historical control group from the same institution. No NED 137-related toxicity has been noted to date.
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Authors | R E Falk, L Makowka, N A Nossal, L E Rotstein, J A Falk |
Journal | Surgery
(Surgery)
Vol. 88
Issue 1
Pg. 126-36
(Jul 1980)
ISSN: 0039-6060 [Print] United States |
PMID | 6992317
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Adjuvants, Immunologic
- Antigens, Neoplasm
- Antineoplastic Agents
- Polymers
- carboxyimamidate
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Topics |
- Adenocarcinoma
(drug therapy)
- Adjuvants, Immunologic
(adverse effects, therapeutic use)
- Adult
- Aged
- Animals
- Antibody Formation
(drug effects)
- Antigens, Neoplasm
- Antineoplastic Agents
(therapeutic use)
- Carcinoma
(drug therapy)
- Clinical Trials as Topic
- Female
- Gastrointestinal Neoplasms
(drug therapy)
- Humans
- Immunity, Cellular
(drug effects)
- Immunotherapy
- Male
- Mammary Neoplasms, Experimental
(immunology, therapy)
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Transplantation
- Neoplasms, Experimental
(immunology, therapy)
- Pancreatic Neoplasms
(drug therapy)
- Polymers
(adverse effects, therapeutic use)
- Rats
- Transplantation, Homologous
- Urinary Bladder Neoplasms
(immunology, therapy)
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