Abstract |
Routine screening of 404 742 sera by the automated micro-haemagglutination assay ( AMHA-TP) and the Venereal Disease Research Laboratory (VDRL) test showed that 9848 specimens gave a reactive result to one of the three assays. Reactive results were confirmed by the fluorescent treponemal antibody absorption (FTA-ABS) test. The possibility of false-positive results varied from 0.04-0.38% of all specimens or from 1.7-15.7% of reactive sera. The VDRL test failed to detect reactivity in 56.54% of sera from patients who had previously been infected with Treponema pallidum. The importance of routine testing by the AMHA-TP is illustrated by the detection of four patients with mesaortitis and two with active neurosyphilis among a selected group of 54 patients who had non-reactive results to the VDRL test. Testing of cerebrospinal fluid specimens by the AMHA-TP test produced more specific results than by the other two tests.
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Authors | A Luger, B Schmidt, I Spendlingwimmer, F Horn |
Journal | The British journal of venereal diseases
(Br J Vener Dis)
Vol. 56
Issue 1
Pg. 12-6
(Feb 1980)
ISSN: 0007-134X [Print] England |
PMID | 6989443
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Antibodies, Bacterial
- Autoanalysis
- Fluorescent Antibody Technique
- Hemagglutination Tests
- Humans
- Syphilis
(cerebrospinal fluid)
- Syphilis Serodiagnosis
(methods)
- Treponema pallidum
(immunology)
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