A randomized, double-blind therapeutic trial of 0.25% desoxymethasone and 0.1% hydrocortisone 17-butyrate in the treatment of varicose eczema.

Abstract

A double-blind, randomized trial was carried out in 60 patients with varicose (hypostatic) eczema to compare the efficacy and tolerance of treatment with 0.25% desoxymethasone in an oily cream base, the oily cream base alone, and 0.1% hydrocortisone 17-butyrate cream. The creams were applied twice daily and patients' progress followed for up to 38 days. Clinical ratings based on an assessment of individual signs and symptoms, the area of skin involved and the physician's overall impression demonstrated a significant difference from the oily cream base in favour of both active treatments within the first 10 days. No significant difference between the two active treatments was shown. All three treatments were well tolerated by the patients.

• Authors: M Henry, G Hanks, A Whelan
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 6 Issue 7 Pg. 502-6 ( 1980) ISSN: 0300-7995 [Print] England
• PMID: 6988176 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Oils
• Ointment Bases
• Pharmaceutical Vehicles
• Desoximetasone
• Dexamethasone
• Hydrocortisone

Topics

• Administration, Topical
• Clinical Trials as Topic
• Desoximetasone (administration & dosage, adverse effects, therapeutic use)
• Dexamethasone (analogs & derivatives)
• Double-Blind Method
• Eczema (drug therapy, etiology)
• Female
• Humans
• Hydrocortisone (administration & dosage, adverse effects, therapeutic use)
• Male
• Middle Aged
• Oils
• Ointment Bases
• Pharmaceutical Vehicles
• Varicose Veins (complications)