[Clinical trial of K-247].

Abstract

The clinical trial of K-247, an anticancer drug showing antitumor effect by new mechanism of action, was performed in a total of 22 patients with a variety of advanced cancers, consisting of 10 cases administered singly and 12 cases combined with other anticancer agents. All patients were treated three or four times every day with oral administration of K-247 (600-800 mg/day). Including one patient receiving a high dosage (over 200 g totally) of K-247, in all cases, no appreciable side effect causing suspension of the administration was recognized. In combination therapies with other anticancer drugs there was rather found a tendency to rescue WBC from decrease. As a clinical result, although all cases tested were insusceptible to prior chemotherapy with various anticancer drugs, one case, which has received palliative operation for rectal cancer accompanied with pelvic infiltration, was experienced after administration of K-247 only, in which the destructive lesion of left sacral on X-ray photograph was restored to almost normal condition and the patient's complaints such as severe pain in the lower legs and difficulty in walking were completely disappeared.

• Authors: R Kanamaru, K Takahashi, Y Mitachi, M Kanbe, T Sato, H Kakuta, A Wakui
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 9 Issue 12 Pg. 2122-7 (Dec 1982) ISSN: 0385-0684 [Print] Japan
• PMID: 6985188 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Aminobenzoates
• Antineoplastic Agents
• para-Aminobenzoates
• 4-aminobenzoic acid-N-xyloside
• 4-Aminobenzoic Acid

Topics

• 4-Aminobenzoic Acid (administration & dosage, therapeutic use)
• Adult
• Aged
• Aminobenzoates (therapeutic use)
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Breast Neoplasms (drug therapy)
• Female
• Humans
• Lung Neoplasms (drug therapy)
• Male
• Middle Aged
• Neoplasms (drug therapy)
• Rectal Neoplasms (drug therapy)
• para-Aminobenzoates