[Anti-inflammatory, analgesic and anti-pyretic activities of a non-steroidal anti-inflammatory drug, etofenamate, in experimental animals].

Abstract

Anti-inflammatory, analgesic, and anti-pyretic activities of orally administered etofenamate, the diethylene glycol ester of flufenamic acid, were investigated in experimental animals. Against acetic acid-induced vascular permeability in mice and ultra-violet light-induced erythema in guinea pigs, etofenamate produced a dose related inhibition at doses of 40--320 mg/kg and 5--20 mg/kg, respectively. In rats, felt-pellet-induced granuloma formation and adjuvant-induced arthritis were significantly inhibited by repeated administration of etofenamate at doses of 20 mg/kg/day for 5 days and 40 mg/kg/day for 21 days, respectively. Etofenamate showed an inhibitory activity on the squeak response caused by flexing and extending the silver nitrate-induced arthritic joint in rats; and it produced a dose related anti-writhing activity at doses of 50--300 mg/kg and 10--80 mg/kg in mice and rats, respectively, in the acetic acid-induced writhing test. Etofenamate showed a significant anti-pyretic activity at doses of 0.2 mg/kg or more. These potencies of etofenamate were 0.5 to 1.6 times those of flufenamic acid. In particular, the anti-erythema, anti-arthritis, and anti-pyretic activities of etofenamate were approximately equivalent to or superior to those of flufenamic acid. From these results, it was suggested that etofenamate given orally, like other non-steroidal anti-inflammatory drugs, showed anti-inflammatory, analgesic, and anti-pyretic activities in experimental animals.

• Authors: H Nakamura, S Motoyoshi, C Imazu, K Ishii, Y Yokoyama, Y Seto, T Kadokawa, M Shimizu
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 80 Issue 2 Pg. 125-35 (Aug 1982) ISSN: 0015-5691 [Print] Japan
• PMID: 6983482 (Publication Type: English Abstract, Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Flufenamic Acid
• etofenamate

Topics

• Analgesics
• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal
• Arthritis, Experimental (prevention & control)
• Capillary Permeability (drug effects)
• Disease Models, Animal
• Erythema (drug therapy)
• Female
• Flufenamic Acid (analogs & derivatives, pharmacology, therapeutic use)
• Granuloma (drug therapy)
• Guinea Pigs
• Male
• Mice
• Rats
• Rats, Inbred Strains