Disseminated mycobacterial histiocytosis due to M. Fortuitum associated with helper T-lymphocyte immune deficiency.

Abstract

Mycobacterial histiocytosis is a rare disease usually associated with haematological or immunological disorders. We report a fatal case caused by M. fortuitum infection showing the typical disseminated histiocytosis. Immunological investigations revealed impaired cellular immunity demonstrated by negative skin tests with different "recall-antigens", and in vitro an isolated defect of helper T-lymphocytes in the peripheral blood which in combination with hypergammaglobulinemia suggests a "lymphocyte and distribution syndrome".

• Authors: B D Bültmann, H D Flad, E Kaiserling, H K Müller-Hermelink, G Kratzsch, J Galle, W Schachenmayr, H Heimpel, H J Wigger, O Haferkamp
• Journal: Virchows Archiv. A, Pathological anatomy and histology (Virchows Arch A Pathol Anat Histol) Vol. 395 Issue 2 Pg. 217-25 ( 1982) ISSN: 0340-1227 [Print] Germany
• PMID: 6980529 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Autopsy
• Humans
• Immunologic Deficiency Syndromes (complications, pathology)
• Lymph Nodes (pathology)
• Lymphatic Diseases (complications, etiology)
• Male
• Mycobacterium Infections, Nontuberculous (complications, pathology)
• T-Lymphocytes