Skeletal manifestations in cutaneous T-cell lymphomas.

Abstract

The clinical course of three patients with cutaneous T-cell lymphoma (CTCL) in whom skeletal disease developed is presented and the literature on skeletal involvement in these disorders is reviewed. Three separate types of skeletal manifestations occurred: (1) osteolytic lesions, (2) osteoblastic lesions, and (3) diffuse osteoporosis. Hypercalcemia was present in two cases. Tumor cells from two patients in short-term culture secreted osteoclast-activating factor(s). Both of these patients had pathologic evidence of osteoclast activation in bone sections. Thus, the tumor cells in certain patients with CTCL may derive from a monoclonal proliferation of a T-cell subset capable of producing humoral bone-resorbing factor(s) similar to those demonstrated in cultures of mitogen- and antigen-activated normal lymphocytes. Since skeletal lesions are unusual, it would follow that other T-cell subsets account for pathologic cell proliferation in most patients with CTCL.

• Authors: B A Brigham, P A Bunn Jr, J E Horton, G P Schechter, L M Wahl, E C Bradley, N R Dunnick, M J Matthews
• Journal: Archives of dermatology (Arch Dermatol) Vol. 118 Issue 7 Pg. 461-7 (Jul 1982) ISSN: 0003-987X [Print] United States
• PMID: 6979976 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Resorption (etiology, physiopathology)
• Female
• Humans
• Hypercalcemia (etiology)
• Male
• Middle Aged
• Mycosis Fungoides (complications)
• Osteoporosis (etiology)
• Osteosclerosis (etiology)
• Sezary Syndrome (complications)
• Skin Neoplasms (complications)
• T-Lymphocytes (ultrastructure)