[Treatment of initial urinary tract infection in children with cotrifamole and cotrimoxazole. A double-blind study].

Abstract	28 children with initial episodes of urinary tract infection were treated with cotrimoxazole or cotrifamole (dose ratio 3 : 2) for 14 days in a prospective randomized double blind trial. The two groups did not differ as regards clinical signs. The efficacy and cure rates of each regimen were similar. Laboratory studies (hemoglobin, WBC, liver, and renal function) showed no differences between both groups before and after therapy; an alteration of the laboratory values could not be observed during therapy. The number of children with X-ray abnormalities of kidneys and urinary tract was similar in both groups. During an observation time of up to 12 months after the first urinary tract infection no differences in the number of reinfections and relapses were observed. As a result of this study, we recommend cotrifamole in a lower dose (ratio 2 : 3) than cotrimoxazole for the treatment of urinary tract infection.
Authors	H P Weber, U Aberfeld, G Hildenbrand, G Knöpfle
Journal	Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 107 Issue 24 Pg. 837-41 (Jun 18 1982) ISSN: 0012-0472 [Print] Germany
Vernacular Title	Behandlung von ersten Harnwegsinfekten im Kindesalter mit Cotrifamol und Cotrimoxazol.
PMID	6979475 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Anti-Infective Agents, Urinary Drug Combinations sulfamoxole, trimethoprim drug combination Trimethoprim, Sulfamethoxazole Drug Combination Trimethoprim Sulfamoxole Sulfamethoxazole
Topics	Adolescent Anti-Infective Agents, Urinary (therapeutic use) Child Child, Preschool Double-Blind Method Drug Combinations (therapeutic use) Female Humans Male Radiography Random Allocation Recurrence Sulfamethoxazole (therapeutic use) Sulfamoxole (therapeutic use) Trimethoprim (therapeutic use) Trimethoprim, Sulfamethoxazole Drug Combination Urinary Tract Infections (diagnostic imaging, drug therapy)

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