Abstract |
The serological response of children to two doses of live oral poliomyelitis vaccine (the first at age 3-8 months and the second at age 9-14 months) and to one dose of measles vaccine (at age 9-14 months) was determined in two regions of Ghana. The seroconversion rates after two doses of poliomyelitis vaccine were lower than expected-24% for poliovirus type 1, 60% for type 2, and 52% for type 3; 23% of the subjects were triple negative. A third dose of the vaccine increased the seroconversion rates to 36%, 73%, and 61% for poliovirus types 1, 2, and 3, respectively; the rate for triple negatives fell to 8%. In the course of the study it was found that there was an intensive circulation of wild polioviruses and that a high proportion of 3-8 month-old infants had maternal antibodies.The seroconversion rate following one dose of measles vaccine was about 90%, a response similar to that obtained in temperate climates. The two main conclusions drawn from the study were: (1) two doses of poliomyelitis vaccine are inadequate to provide protection against poliomyelitis in developing countries; and (2) in developing countries measles vaccine should be given as soon as possible after the age of 8 months.
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Authors | M Böttiger, S Litvinov, F Assaad, H Lundbeck, L Heller, E G Beausoleil |
Journal | Bulletin of the World Health Organization
(Bull World Health Organ)
Vol. 59
Issue 5
Pg. 729-36
( 1981)
ISSN: 0042-9686 [Print] Switzerland |
PMID | 6976234
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Measles Vaccine
- Poliovirus Vaccine, Oral
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Topics |
- Antibodies, Viral
(immunology)
- Ghana
- Humans
- Infant
- Measles
(immunology, prevention & control)
- Measles Vaccine
(immunology)
- Poliomyelitis
(immunology)
- Poliovirus Vaccine, Oral
(immunology)
- Serologic Tests
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