Fluproquazone in the management of strains and sprains.

Abstract

A double-blind randomized trial was carried out in 59 patient suffering from moderately severe to severe strains and sprains to compare the efficacy of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) in the relief of pain. Patients received either 50 mg or 100 mg fluproquazone up to 6 times daily for 3 days. The results of subjective assessments showed that after 2 days pain had either completely resolved or markedly improved in all patients. Both treatments were equally effective in relieving both spontaneous pain and pain on movement after 1 and 2 days. No differences were found between the two groups in the patients' overall evaluation of treatment or physicians' assessment of therapeutic response. Both dosage were well tolerated during the short-term trial.

• Authors: V Jaegemann, E Kolb, J Pabst, X Lataste
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 31 Issue 5a Pg. 929-31 ( 1981) ISSN: 0004-4172 [Print] Germany
• PMID: 6973989 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Placebos
• Quinazolines
• Quinazolinones
• fluproquazone

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Placebos
• Quinazolines (therapeutic use)
• Quinazolinones
• Sprains and Strains (drug therapy)