Abstract |
In cultures of human peripheral lymphocytes the frequencies of Trenimon-induced SCEs in second post-treatment metaphases and of structural chromosomal aberrations in first, second and third post-treatment metaphases were clearly lower at late as compared with early fixation times. These results, which are discussed, indicate that T cells (early dividing) are more sensitive with respect to the induction of SCEs and structural chromosomal aberrations by Trenimon as compared with B cells (late dividing).
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Authors | L Riedel, G Obe |
Journal | Mutation research
(Mutat Res)
Vol. 73
Issue 1
Pg. 125-31
(Nov 1980)
ISSN: 0027-5107 [Print] Netherlands |
PMID | 6973084
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- B-Lymphocytes
(drug effects)
- Cell Cycle
- Cell Division
- Chromosome Aberrations
- Crossing Over, Genetic
(drug effects)
- Humans
- Lymphocytes
(drug effects)
- Male
- Metaphase
- Sister Chromatid Exchange
(drug effects)
- T-Lymphocytes
(drug effects)
- Time Factors
- Triaziquone
(pharmacology)
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