Genetic background of acute anterior uveitis.

Abstract

To determine the hereditary pattern of acute anterior uveitis, we examined seven families-one family with four cases, one family with three cases, and four families with two cases of acute anterior uveitis. A total of 16 patients with uveitis and 28 relatives underwent ocular examinations and serologic determination of HLA antigens, protease inhibitor alpha 1-antitrypsin typing, and X-ray examination of sacroiliac joints. Sacroiliitis was found in 11 of 16 patients (68.8%) and incomplete Reiter's disease in seven of 16 (43.8%). HLA-B27 antigen was found in all patients with uveitis and in six of 21 (28.6%) relatives. HLA-Cw1 antigen was found in nine of 14 (64.3%) patients with uveitis, often in the same haplotype with HLA-B27 antigen. HLA-DR4 antigen was found in seven of 11 (63.6%) patients with uveitis. There was no significant association of the alpha 1-antitrypsin variant MZ with uveitis. We believe that a pleiotropic gene associated with HLA-B27 antigen with autosomal dominant inheritance, incomplete penetrance, and variable expressivity may determine susceptibility to acute anterior uveitis in linkage disequilibrium with HLA-Cwl antigen.

• Authors: A Tiilikainen, S Koskimies, A Eriksson, R Frants
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 91 Issue 6 Pg. 711-20 (Jun 1981) ISSN: 0002-9394 [Print] United States
• PMID: 6972700 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA Antigens
• alpha 1-Antitrypsin

Topics

• Acute Disease
• Adult
• Aged
• Arthritis, Reactive (diagnosis)
• Female
• HLA Antigens (analysis)
• Humans
• Inflammation
• Male
• Middle Aged
• Pedigree
• Radiography
• Sacroiliac Joint (diagnostic imaging)
• Uveitis (genetics)
• alpha 1-Antitrypsin (genetics)