Abstract |
The adjuvant and tumor-suppressive activities of the quinonyl [2,3-dimethoxy-5-methyl-6-(9'-carboxynonyl)-1,4- benzoquinone (QS-10)] derivatives of N-acetyl muramyl dipeptides were examined. N-Acetyl muramyl-L-valyl-D- isoglutamine ( MurNac-L-Val-D-isoGln), QS-10-MurNAc-L-Val-D-isoGln, and their methyl esters were shown to have potent adjuvant activity on the induction of delayed-type hypersensitivity to monoazobenzenarsonate-N- acetyl-L-tyrosine in guinea pigs and on the primary immune response against sheep erythrocytes in vitro; however, only QS-10-MurNAc-L-Val-D-isoGln methyl ester, i.e., QS-10-MurNAc-L-Val-D-Glu(OCH3)NH2 (quinonyl-MDP-66), was shown to be an active adjuvant for the induction of allogeneic killer T cells in mice and the suppression of tumor growth in syngeneic mice when it was administered as a suspension in phosphate-buffered saline. The effectiveness of the chain length of the quinonyl moiety in quinonyl-MDP-66 and the replacement of the L-valine residue with L-serine or L-threonine were also examined in comparison with the adjuvant and tumor-suppressive activities of quinonyl-MDP-66.
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Authors | I Saiki, Y Tanio, M Yamawaki, M Uemiya, S Kobayashi, T Fukuda, H Yukimasa, Y Yamamura, I Azuma |
Journal | Infection and immunity
(Infect Immun)
Vol. 31
Issue 1
Pg. 114-21
(Jan 1981)
ISSN: 0019-9567 [Print] United States |
PMID | 6971259
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Immunologic
- Antineoplastic Agents
- Glycopeptides
- Acetylmuramyl-Alanyl-Isoglutamine
- quinonyl-MDP-66
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Topics |
- Acetylmuramyl-Alanyl-Isoglutamine
(analogs & derivatives, pharmacology)
- Adjuvants, Immunologic
- Animals
- Antibody Formation
- Antineoplastic Agents
- Cytotoxicity, Immunologic
- Female
- Glycopeptides
(pharmacology)
- Guinea Pigs
- Hypersensitivity, Delayed
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Structure-Activity Relationship
- T-Lymphocytes
(immunology)
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