Surface antigens on malignant Sézary and T-CLL cells correspond to those of mature T cells.

Abstract

Tumor cells from eight adult patients with T-cell chronic malignancies were investigated with a series of monoclonal antibodies recognizing T-cell differentiation antigens. This series allowed definition of discrete subpopulations of mature T cells with functional specialization. All six patients with Sézary syndrome and one patient with T-chronic lymphocytic leukemia had cells with the same phenotype as normal helper/inducer T cells, whereas the other patient with T-chronic lymphocytic leukemia had cell with the same phenotype as normal cytotoxic/suppressor T cells. Some clinical manifestations observed in these patients may reflect retention of functional activities by their malignant cells.

• Authors: L Boumsell, A Bernard, E L Reinherz, L M Nadler, J Ritz, H Coppin, Y Richard, L Dubertret, F Valensi, L Degos, J Lemerle, G Flandrin, J Dausset, S F Schlossman
• Journal: Blood (Blood) Vol. 57 Issue 3 Pg. 526-30 (Mar 1981) ISSN: 0006-4971 [Print] United States
• PMID: 6970053 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Surface

Topics

• Antibody Specificity
• Antigens, Surface (analysis)
• Female
• Humans
• Leukemia, Lymphoid (immunology)
• Male
• Middle Aged
• Sezary Syndrome (immunology)
• Spleen (cytology)
• T-Lymphocytes (immunology)