HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Simultaneous evaluation of pancreatic exocrine function and intestinal absorptive function in dogs with chronic diarrhea.

Abstract
The N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BT-PABA):xylose test was evaluated in 5 clinically normal dogs, 5 dogs with pancreatic exocrine insufficiency (PEI), and 7 dogs with intestinal malabsorption. A solution of BT-PABA (1 g/100 ml) and d-xylose (10 g/100 ml) was given orally (5 ml/kg of body weight) to dogs in each group. Plasma p-aminobenzoic acid (PABA) curves were decreased in dogs with PEI and intestinal malabsorption (P < 0.05) but were the lowest in dogs with PEI, compared with clinically normal dogs. Xylose values in dogs with malabsorption were decreased (P < 0.05), compared with clinically normal dogs. Dogs with PEI had plasma xylose values that were intermediate to values in clinically normal dogs and dogs with intestinal malabsorption. Results of BT-PABA:xylose testing were compared with results of sodium PABA:xylose testing, to determine whether decreased PABA values obtained by the BT-PABA:xylose test were caused by free PABA malabsorption or by maldigestion of BT-PABA. The sodium PABA:xylose test was performed in dogs from each group by oral administration of a solution (5 ml/kg) of sodium PABA (0.372 g/100 ml) and d-xylose (10.0 g/100 ml). Plasma PABA values obtained by the sodium PABA:xylose test were similar in each group. Thus, different PABA values obtained by the BT-PABA:xylose test were not caused by PABA malabsorption. Xylose values were similar to values obtained by the BT-PABA:xylose test. It was concluded that: (1) the BT-PABA:xylose test is a practical test for detecting maldigestion or malabsorption in the dog; (2) dogs with intestinal malabsorption may have functional PEI; and (3) decreased PABA plasma values obtained by BT-PABA:xylose testing are not caused by malabsorption of free PABA.
AuthorsW A Rogers, R P Stradley, R G Sherding, J Powers, C R Cole
JournalJournal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 177 Issue 11 Pg. 1128-31 (Dec 01 1980) ISSN: 0003-1488 [Print] United States
PMID6969249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Xylose
  • 4-Aminobenzoic Acid
Topics
  • 4-Aminobenzoic Acid
  • Animals
  • Chronic Disease
  • Diarrhea (diagnosis, metabolism, veterinary)
  • Dog Diseases (diagnosis, metabolism)
  • Dogs
  • Intestinal Absorption
  • Pancreas (metabolism)
  • Xylose

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: