Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats.

Abstract

Nisoxetine and desipramine (inhibitors of norepinephrine reuptake) each exerted a suppressant effect on spinal cord seizures by decreasing the duration of tonic extension. In addition, desipramine increased the duration of tonic flexion and nisoxetine decreased the total duration of seizure. In contrast, citalopram (an inhibitor of 5-hydroxytryptamine reuptake) did not affect any of these seizure components. These observations support the concept that spinal cord noradrenergic, but not 5-hydroxytryptaminergic neurons act as attenuators of convulsive activity.

• Authors: P C Jobe, T B Ray
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 30 Issue 1 Pg. 185-8 (Oct 1980) ISSN: 0034-5164 [Print] United States
• PMID: 6968962 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Benzofurans
• Propylamines
• Serotonin Antagonists
• Fluoxetine
• Citalopram
• nisoxetine
• Desipramine
• Norepinephrine

Topics

• Animals
• Benzofurans (pharmacology)
• Citalopram
• Desipramine (pharmacology)
• Electric Stimulation
• Female
• Fluoxetine (analogs & derivatives, pharmacology)
• Norepinephrine (antagonists & inhibitors)
• Propylamines (pharmacology)
• Rats
• Seizures (prevention & control)
• Serotonin Antagonists (pharmacology)
• Spinal Cord (physiology)