Preliminary experience with ICI 35 868 as an i.v. induction agent: comparison with althesin.

Abstract

In a small open dose-finding study the i.v. dose of ICI 35 868 required to induce anaesthesia in healthy adults was 2 mg kg-1. Comparison of this dose with Althesin 0.05 ml kg-1 for i.v. induction, both injected over 30 s suggests that they have similar effects on heart rate, arterial pressure and breathing. The mean times to loss of eyelash reflex were 57 +/- SD 10.1 s (ICI 35 868) and 46 +/- 3.9s (Althesin). The new drug was associated with pain and discomfort on injection in seven of 10 patients, but with less involuntary movement than occurred with Althesin.

• Authors: K M Rogers, K M Dewar, T D McCubbin, A A Spence
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 52 Issue 8 Pg. 807-10 (Aug 1980) ISSN: 0007-0912 [Print] England
• PMID: 6968567 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Anesthetics
• Phenols
• Alfaxalone Alfadolone Mixture
• Propofol

Topics

• Adolescent
• Adult
• Alfaxalone Alfadolone Mixture (administration & dosage, pharmacology)
• Anesthesia, Intravenous (methods)
• Anesthetics (administration & dosage, pharmacology)
• Double-Blind Method
• Drug Administration Schedule
• Drug Evaluation
• Hemodynamics (drug effects)
• Humans
• Middle Aged
• Phenols (administration & dosage, pharmacology)
• Propofol