Characterization of the glomerular antibody in acute poststreptococcal glomerulonephritis.

Abstract

Glomerular-fixed antibody was eluted from the kidney of a 17-year-old patient who died 2 weeks after the onset of acute poststreptococcal glomerulonephritis. Elevated titers of antibodies to streptococcal enzymes were found in the serum but not in the glomerular eluate. Streptococcal M protein and anti-M protein reactivity were not detected in the eluate. Immunoglobulin G was the only serum protein demonstrated in the eluate, and it was found to have anti-IgG activity highly concentrated with respect to the serum. These studies appear to indicate that anti-IgG is involved in the immune pathogenesis of acute poststreptococcal glomerulonephritis. Native IgG may be rendered autoimmunogenic by the streptococcus with subsequent antibody production to the neoautoimmunogen. Alernatively, anti-IgG may be produced to the IgG incorporated in an exogenous streptococcal antigen-antibody complex.

• Authors: B Rodríguez-Iturbe, D Rabideau, R García, L Rubio, R M McIntosh
• Journal: Annals of internal medicine (Ann Intern Med) Vol. 92 Issue 4 Pg. 478-81 (Apr 1980) ISSN: 0003-4819 [Print] United States
• PMID: 6965830 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Anti-Idiotypic
• Bacterial Proteins
• Immunoglobulin G

Topics

• Adolescent
• Antibodies, Anti-Idiotypic (analysis, immunology)
• Antibody Formation
• Bacterial Proteins (immunology)
• Female
• Glomerulonephritis (immunology)
• Humans
• Immunoglobulin G (immunology)
• Kidney Glomerulus (immunology)
• Streptococcal Infections (complications)