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Aetiology of sympathetic ophthalmitis.

Abstract
The aetiology of sympathetic ophthalmitis is still unknown. Recent investigations on patients and experimental studies on allergic uveitis in guinea-pigs suggest that sympathetic ophthalmitis may be due to delayed hypersensitivity to one of the retinal antigens associated with photoreceptor membranes (called the retinal 's' antigen). It is postulated that a penetrating injury causes a reversal of normal tolerance by introducing an adjuvant effect from bacterial or viral contamination along with the release of the intraocular antigen. The antigen then gains access to the regional lymphatics by way of the penetrating wound. A specific cell-mediated immune response is then initiated followed by the onset of sympathetic ophthalmitis.
AuthorsN A Rao, V G Wong
JournalTransactions of the ophthalmological societies of the United Kingdom (Trans Ophthalmol Soc U K (1962)) Vol. 101 (Pt 3) Issue 3 Pg. 357-60 (Sep 1981) ISSN: 0078-5334 [Print] England
PMID6963825 (Publication Type: Journal Article)
Chemical References
  • Antigens
  • Melanins
Topics
  • Animals
  • Antigens (immunology)
  • Eye Injuries (complications)
  • Guinea Pigs
  • Melanins (immunology)
  • Melanocytes (immunology)
  • Ophthalmia, Sympathetic (etiology, immunology)
  • Pigment Epithelium of Eye (immunology)
  • Rats
  • Retina (immunology)
  • Uvea (immunology)
  • Wounds, Penetrating (complications)

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