Abstract |
HLA-A, -B, -C, and -DR antigens were determined in order to study the association of HLA in Japanese patients with several autoimmune diseases, hypertrophic cardiomyopathy, and Hodgkin's disease. The frequency of HLA-DR4 was significantly increased in the patients with rheumatoid arthritis, juvenile-onset insulin-dependent diabetes mellitus ( IDDM) and hypertrophic obstructive cardiomyopathy. In this study, no significant associations with A, B, or C specificities were observed except BW22 in IDDM. In contrast, the negative association with HLA-DR2 was observed in Hashimoto's thyroiditis, pemphigus vulgaris and hypertrophic non-obstructive cardiomyopathy.
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Authors | T Sakurami, Y Ueno, Y Iwaki, M S Park, P I Terasaki, H Saji |
Journal | Tissue antigens
(Tissue Antigens)
Vol. 19
Issue 2
Pg. 129-33
(Feb 1982)
ISSN: 0001-2815 [Print] England |
PMID | 6954729
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- HLA Antigens
- HLA-DR Antigens
- Histocompatibility Antigens Class II
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Topics |
- Arthritis, Rheumatoid
(immunology)
- Autoimmune Diseases
(immunology)
- Cardiomyopathy, Hypertrophic
(immunology)
- Diabetes Mellitus, Type 1
(immunology)
- Genetic Linkage
- Graves Disease
(immunology)
- HLA Antigens
- HLA-DR Antigens
- Histocompatibility Antigens Class II
(genetics)
- Humans
- Japan
- Pemphigus
(immunology)
- Thyroiditis, Autoimmune
(immunology)
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