Water metabolism after cisplatin in the rat.

A polyuric state is often observed after cis-dichlorodiammine platinum (cisplatin). To study the mechanism of this polyuria we gave 5-6 mg/kg cisplatin to conscious rats and observed polydipsia and a polyuric form of mild acute renal failure. A defect in renal concentrating ability was observed 1 and 8 days after cisplatin. Animals demonstrated diminished postdehydration plasma vasopressin at 1 but not at 8 days after cisplatin, and exogenous vasopressin corrected the renal concentration defect at 1 but not at 8 days after cisplatin. To assess the role of polydipsia in the concentration defect, water intake in cisplatin-treated animals was matched to pair-fed controls. Prevention of polydipsia improved the polyuria but not the concentration defect seen 8 days after cisplatin. To assess intrarenal factors in the renal concentration defect, postdehydration interstitial solute was measured and was significantly lower in cisplatin-treated than in control animals. To determine whether the diminished interstitial solute was due to vascular mechanisms, inner medullary plasma flow was measured and was identical in cisplatin-treated and control rats. Treatment with cisplatin also resulted in decreased excretion of a water load. We conclude that either impaired synthesis or release of vasopressin is the cause of the impaired renal concentration seen 1 day after cisplatin. Eight days after cisplatin, the renal concentration defect is due in part to decreased interstitial tonicity.
AuthorsJ A Gordon, L N Peterson, R J Anderson
JournalThe American journal of physiology (Am J Physiol) Vol. 243 Issue 1 Pg. F36-43 (Jul 1982) ISSN: 0002-9513 [Print] UNITED STATES
PMID6953767 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Prostaglandins E
  • Vasopressins
  • Arginine Vasopressin
  • Inulin
  • Dinoprostone
  • Cisplatin
  • p-Aminohippuric Acid
  • Animals
  • Arginine Vasopressin (secretion)
  • Body Water (metabolism)
  • Cisplatin (pharmacology)
  • Dinoprostone
  • Drinking
  • Inulin (metabolism)
  • Kidney Medulla (physiology, physiopathology)
  • Male
  • Polyuria (physiopathology)
  • Prostaglandins E (urine)
  • Rats
  • Rats, Inbred Strains
  • Vasopressins (pharmacology)
  • p-Aminohippuric Acid (metabolism)

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