Abstract |
HLA--B8 and/or Bw15, associated with juvenile onset insulin-dependent diabetes mellitus (JDM) in Caucasians, have a very low frequency in the Japanese population. Thus, we were interested in investigating the association between JDM and HLA antigen in a Japanese population. Eighty-nine patients with JDM and 128 unrelated random controls were HLA-typed by the microlymphocytotoxicity test. The data revealed a significant, positive association between this type of diabetes mellitus and HLA--Bw54 (Bw22-J, J-1) antigen (Japanese-specific split antigen of HLA--Bw22).
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Authors | K Okimoto, T Juji, S Ishiba, H Maruyama, H Tohyama, K Kosaka |
Journal | Tissue antigens
(Tissue Antigens)
Vol. 11
Issue 5
Pg. 418-22
(May 1978)
ISSN: 0001-2815 [Print] England |
PMID | 694905
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Cytotoxicity Tests, Immunologic
- Diabetes Mellitus, Type 1
(genetics)
- Female
- HLA Antigens
(analysis)
- Humans
- Japan
- Male
- Risk
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