[HLA-antigens in the diagnosis and genetics of schizophrenia].

Abstract

We found no convincing association of HLA-antigens and Schizophrenia with exception of a significant reduction of Aw19 in our study of 140 schizophrenic patients. The incidence of the haploids HLA-AI,B7, -A2,B18, -A2, Bw35, -A3,Bw35, -A1,Cw3, -A2,Cw3 has been significantly increased and the haploids HLA-A1,B8, -A2,B5, -A2,B7, -A2,Cw2, -B12,Cw4, -B27, Cw2 significantly decreased compared with normals. HLA-A1,B8, -A2,B5, -A2,B7, -A2,Cw2, -B12,Cw2 have shown an important imbalance of the alleles possibly induced by the lowered fertility and migration of schizophrenic patient.

• Authors: H Arnold, K E Bühler, U Hobert, H Bühler
• Journal: Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie (Schweiz Arch Neurol Neurochir Psychiatr) Vol. 129 Issue 2 Pg. 229-40 ( 1981) ISSN: 0036-7273 [Print] Switzerland
• Vernacular Title: HLA-Antigene in Diagnostik und Genetik der Schizophrenie.
• PMID: 6948405 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA Antigens
• HLA-B Antigens
• HLA-C Antigens

Topics

• Female
• Gene Frequency
• Genotype
• HLA Antigens (genetics)
• HLA-B Antigens
• HLA-C Antigens
• Humans
• Male
• Schizophrenia (diagnosis, genetics)