Eastern Cooperative Oncology Group study of the cytochemistry of adult acute myeloid leukemia by correlation of subtypes with response and survival.

Abstract

A study of over 300 adult patients with acute myeloid leukemia has been completed by member institutions of the Eastern Cooperative Oncology Group. A complete remission rate of 51% was achieved. The FAB classification was used with an overall concordance of 61% between investigators and the repository center. Acute monocytic leukemia (M5) and acute erythroleukemia (M6) accounted for 12% of the cases accessioned and had the worst median survival with no patients surviving 2 years. The longest response duration occurred in hypergranular promyelocytic leukemia (M3).

• Authors: J M Bennett, C B Begg
• Journal: Cancer research (Cancer Res) Vol. 41 Issue 11 Pt 2 Pg. 4833-7 (Nov 1981) ISSN: 0008-5472 [Print] United States
• PMID: 6945906 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cytarabine
• Vincristine
• Thioguanine
• Daunorubicin

Topics

• Adult
• Cytarabine (therapeutic use)
• Daunorubicin (therapeutic use)
• Histocytochemistry
• Humans
• Leukemia, Myeloid, Acute (classification, drug therapy, secondary)
• Nervous System Neoplasms (etiology)
• Prognosis
• Thioguanine (therapeutic use)
• Vincristine (therapeutic use)