Effect of 5-methoxytryptophan and 5-methoxytryptamine on the reproductive system of the male golden hamster.

Abstract

S.c. injection of 25 microgram of methoxytryptamine (5-MT) in oil into adult male hamsters given between 4.30 and 5 p.m. (light on from 5 a.m. to 7 p.m.: 14 L/10 D) for 51 consecutive days caused involution of the testes. Similar injections of 5-MT given between 8.30 and 9.30 a.m. completely failed to cause regression of the gonads. Under the same conditions, 5-methoxytryptophan (5-MTP) did not induce gonadal atrophy, neither in the morning nor in the late afternoon. These results indicate that, like malatonin, 5-methoxytryptamine is implicated in the control of the reproductive function.

• Authors: P Pévet, C Haldar-Misra, T Ocal
• Journal: Journal of neural transmission (J Neural Transm) Vol. 51 Issue 3-4 Pg. 303-11 ( 1981) Austria
• PMID: 6945393 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tryptamines
• 5-methoxytryptophan
• 5-Methoxytryptamine
• Tryptophan

Topics

• 5-Methoxytryptamine (pharmacology)
• Animals
• Cricetinae
• Male
• Mesocricetus
• Organ Size (drug effects)
• Reproduction (drug effects)
• Testis (anatomy & histology, drug effects)
• Tryptamines (pharmacology)
• Tryptophan (analogs & derivatives, pharmacology)