Prevention of death from metastases by immune RNA therapy.

Abstract

The effect of immune RNA treatment on the incidence of death from pulmonary metastases was studied in C57BL/6J mice after excision of a B16 murine melanoma. Immune RNA was extracted from the lymphoid tissues of guinea pigs immunized with B16 tumor and then incubated in vitro with normal C57BL/6J mouse splenocytes. Mice receiving intraperitoneal injections of these RNA-treated syngeneic splenocytes after the primary B16 isograft was resectioned showed significantly improved long-term survival (42 to 67 percent in three successive experiments) as compared to control mice (0 to 20 percent survival) receiving untreated splenocytes. The effect of RNA treatment was tumor-specific and ribonuclease sensitive. The results suggest that immunotherapy with immune RNA may be of benefit to certain patients after surgery for cancer.

• Authors: B S Wang, S R Onikul, J A Mannick
• Journal: Science (New York, N.Y.) (Science) Vol. 202 Issue 4363 Pg. 59-60 (Oct 06 1978) ISSN: 0036-8075 [Print] United States
• PMID: 694519 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• RNA

Topics

• Animals
• Immunotherapy (methods)
• Lung Neoplasms (prevention & control)
• Lymphocytes (immunology)
• Melanoma (immunology)
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis (prevention & control)
• Neoplasms, Experimental (immunology)
• RNA (immunology, therapeutic use)
• Spleen (immunology)