[Morphological characteristics of osteogenic sarcoma after chemo-and radiotherapy].

Adriamycin was administered intraarterially and the tumor was irradiated at a total focal dose of 3600 rad in the preoperational period in 25 children suffering from osteogenic sarcoma. Histological examinations of the tumors revealed marked necrobiotic, necrotic and sclerotic changes. Within 2 months after the beginning of the therapy the number of tumor cells decreased, they were localized predominantly in the peripheral parts of the extraosseal component. Later in the same areas new generations of tumor cells were found. In 3 cases tumor cells were completely absent. The results suggest the efficacy of adriamycin in combination with radiation therapy in treatment of osteogenic sarcoma.
AuthorsE N Fedorova
JournalArkhiv patologii (Arkh Patol) Vol. 43 Issue 5 Pg. 51-6 ( 1981) ISSN: 0004-1955 [Print] USSR
Vernacular TitleMorfologicheskaia kharakteristika osteogennoń≠ sarkomy posle khimioluchevoń≠ terapii.
PMID6945073 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Doxorubicin
  • Adolescent
  • Bone Neoplasms (pathology, therapy)
  • Child
  • Doxorubicin (administration & dosage)
  • Female
  • Femoral Neoplasms (pathology, therapy)
  • Fibula (pathology)
  • Humans
  • Male
  • Necrosis
  • Osteosarcoma (pathology, therapy)
  • Preoperative Care
  • Radiotherapy Dosage
  • Sclerosis
  • Tibia (pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: