Nephrotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate.

Abstract

The flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) is known to be activated to a potent mutagen in the Salmonella test system and to induce kidney tumors in long-term feeding studies in mice and rats. Administration of Tris-BP to rats leads to extensive tubular necrosis at doses of 250 mg/kg i.p. and higher. The histological lesion is present in most animals 24 h after administration. There is a close correlation between the increase in kidney weights, the degree of kidney damage and the increase in plasma urea levels. A continuous increase in kidney weights with respect to time is seen, 7 days after a dose of 250 mg/kg i.p. the kidney/body weight ratio is 192% of controls. The kidney damage is not altered by previous phenobarbital-treatment, whereas cobaltous chloride, an inhibitor of cytochrome P-450, slightly reduces the kidney damage.

• Authors: E Dybing, E Søderlund
• Journal: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement (Arch Toxicol Suppl) Vol. 4 Pg. 219-22 ( 1980) ISSN: 0171-9750 [Print] Germany
• PMID: 6933906 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Flame Retardants
• Hydrocarbons, Brominated
• Organophosphates
• Organophosphorus Compounds
• tris(2,3-dibromopropyl)phosphate

Topics

• Animals
• Flame Retardants (toxicity)
• Hydrocarbons, Brominated (toxicity)
• Kidney Diseases (chemically induced, pathology)
• Male
• Necrosis (pathology)
• Organ Size (drug effects)
• Organophosphates
• Organophosphorus Compounds (toxicity)
• Rats
• Time Factors