Abstract |
The flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) is known to be activated to a potent mutagen in the Salmonella test system and to induce kidney tumors in long-term feeding studies in mice and rats. Administration of Tris-BP to rats leads to extensive tubular necrosis at doses of 250 mg/kg i.p. and higher. The histological lesion is present in most animals 24 h after administration. There is a close correlation between the increase in kidney weights, the degree of kidney damage and the increase in plasma urea levels. A continuous increase in kidney weights with respect to time is seen, 7 days after a dose of 250 mg/kg i.p. the kidney/ body weight ratio is 192% of controls. The kidney damage is not altered by previous phenobarbital-treatment, whereas cobaltous chloride, an inhibitor of cytochrome P-450, slightly reduces the kidney damage.
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Authors | E Dybing, E Søderlund |
Journal | Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
(Arch Toxicol Suppl)
Vol. 4
Pg. 219-22
( 1980)
ISSN: 0171-9750 [Print] Germany |
PMID | 6933906
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Flame Retardants
- Hydrocarbons, Brominated
- Organophosphates
- Organophosphorus Compounds
- tris(2,3-dibromopropyl)phosphate
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Topics |
- Animals
- Flame Retardants
(toxicity)
- Hydrocarbons, Brominated
(toxicity)
- Kidney Diseases
(chemically induced, pathology)
- Male
- Necrosis
(pathology)
- Organ Size
(drug effects)
- Organophosphates
- Organophosphorus Compounds
(toxicity)
- Rats
- Time Factors
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