Study of the carcinogenicity of large doses of dimethylnitramine, N-nitroso-L-proline, and sodium nitrite administered in drinking water to rats.

Abstract

Large doses of dimethylnitramine (DMNM), N-nitroso-L-proline (NPRO), and sodium nitrite were administered in the drinking water to MRC Wistar rats for at least 1 year, and the rats were maintained for life. DMNM (total dose, 20 g/kg) produced liver tumors in 25 (69%) of the 36 rats and nasal cavity tumors in 9 (25%) of the rats. NPRO (total dose, 36 g/kg) induced no tumors in 37 treated rats. In the group receiving NaNO2 (3.0 g/liter drinking water; total dose, 63 g/kg), 8 (18%) of 45 rats had forestomach squamous papillomas. The tumor incidence in the NaNO2-treated group was significantly greater than that of 2% in a control group started 11 months earlier, which suggested that the NaNO2 was tumorigenic in this experiment.

• Authors: S S Mirvish, O Bulay, R G Runge, K Patil
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 64 Issue 6 Pg. 1435-42 (Jun 1980) ISSN: 0027-8874 [Print] United States
• PMID: 6929379 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Dimethylamines
• Nitrites
• Nitro Compounds
• Nitrosamines
• Proline
• nitrosoproline
• dimethylnitramine

Topics

• Animals
• Body Weight (drug effects)
• Carcinogens
• Dimethylamines
• Dose-Response Relationship, Drug
• Female
• Lethal Dose 50
• Liver Neoplasms (chemically induced)
• Male
• Nasopharyngeal Neoplasms (chemically induced)
• Neoplasms, Experimental (chemically induced, pathology)
• Nitrites (administration & dosage)
• Nitro Compounds
• Nitrosamines
• Proline (analogs & derivatives)
• Rats
• Stomach Neoplasms (chemically induced)