Protection against anthramycin-induced toxicity in mice by coenzyme Q10.

Abstract

Pretreatment of Swiss Webster mice with coenzyme Q10 (CoQ) markedly reduced the lethality of the antitumor antibiotic anthramycin as well as its ability to decrease ventricular weights. In tumor-bearing mice CoQ pretreatment did not produce any consistent alteration of radioactivity levels in blood, heart, tumor, lungs, kidneys, liver, muscles, brain, or spleen after [15-3H]anthramycin administration. Gross alterations in anthramycin distribution is probably not the mechanism by which CoQ alters the cardiotoxicity and lethality of anthramycin.

• Authors: W C Lubawy, R A Dallam, L H Hurley
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 64 Issue 1 Pg. 105-9 (Jan 1980) ISSN: 0027-8874 [Print] United States
• PMID: 6928034 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzodiazepinones
• Anthramycin
• Ubiquinone

Topics

• Animals
• Anthramycin (antagonists & inhibitors, metabolism, toxicity)
• Benzodiazepinones (antagonists & inhibitors)
• Cardiomyopathies (chemically induced, prevention & control)
• Heart Ventricles (drug effects)
• Male
• Mice
• Organ Size (drug effects)
• Time Factors
• Tissue Distribution
• Ubiquinone (pharmacology)