[Fundamental and clinical studies of PC-904 in pediatrics (author's transl)].

Abstract

The following studies were carried out in pediatric patients. 1. Serum levels of PC-904 were examined in 3 patients by 1 hour intravenous infusion of 20 mg/kg, reaching the peak of 22.5 approximately 25.5 microgram/ml at the end of infusion. Half life was 37 approximately 48 minutes. 2. Investigated in only 1 patient, the urinary excretion rate was 12.9% (0 approximately 6 hours). 3. The effect of PC-904 on blood pressure was examined in 1 patient, and no effect was observed. 4. Clinical effects of PC-904 were examined in 9 patients; urinary tract infection (6 cases) and Salmonella enteritis (3 cases). The daily dose was 32.6 approximately 93.0 mg/kg. The overall clinical effectiveness was 66.7%. As to causative organisms E. coli, Klebsiella and Salmonella were isolated. The clinical effects by the organisms were 100%, 0%, and 66.7%, respectively. 5. Slight elevation of GOT and GPT and eosinophilia were observed in each one case but these abnormalities rapidly returned to pre-treatment levels when the administration was discontinued. No other side effects were noticed.

• Authors: S Nanri, K Sunakawa, N Hara, Y Ichihashi, K Hirooka, M Izeki
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 31 Issue 7 Pg. 366-70 (Jul 1978) ISSN: 0368-2781 [Print] Japan
• PMID: 691260 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Naphthyridines
• Ampicillin

Topics

• Adolescent
• Age Factors
• Ampicillin (administration & dosage, analogs & derivatives, metabolism, therapeutic use)
• Blood Pressure (drug effects)
• Child
• Child, Preschool
• Drug Evaluation
• Enteritis (drug therapy)
• Female
• Humans
• Infant
• Injections, Intravenous
• Male
• Naphthyridines (administration & dosage, metabolism, therapeutic use)
• Urinary Tract Infections (drug therapy)