The moderation of elastase-induced emphysema in the hamster by intratracheal pretreatment or post-treatment with succinyl alanyl alanyl prolyl valine chloromethyl ketone.

Abstract

The capacity of the synthetic elastase inhibitor, succinyl alanyl alanyl prolyl valine chloromethyl ketone (CMK), to moderate elastase-induced emphysema in hamsters was examined using morphometric and physiologic measurements. When 0.5 mg of CMK in saline was injected intratracheally 1 h before the intratracheal injection of 0.1 mg of porcine pancreatic elastase, the hamsters did not develop emphysema. When CMK was injected intratracheally 1 h after elastase, the severity of emphysema was reduced by approximately 50% compared with control animals receiving saline 1 h after elastase. The CMK was ineffective when administered intratracheally 4 h after elastase.

• Authors: P J Stone, E C Lucey, J D Calore, G L Snider, C Franzblau, M J Castillo, J C Powers
• Journal: The American review of respiratory disease (Am Rev Respir Dis) Vol. 124 Issue 1 Pg. 56-9 (Jul 1981) ISSN: 0003-0805 [Print] United States
• PMID: 6911015 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amino Acid Chloromethyl Ketones
• Enzyme Inhibitors
• succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone
• Pancreatic Elastase

Topics

• Amino Acid Chloromethyl Ketones (administration & dosage, therapeutic use)
• Animals
• Cricetinae
• Enzyme Inhibitors
• Injections
• Mesocricetus
• Pancreatic Elastase (administration & dosage, antagonists & inhibitors, metabolism)
• Pulmonary Emphysema (chemically induced, enzymology)
• Trachea