Do fat emulsions protect against infusion thrombophlebitis? An experimental study.

Abstract

The clinical experience that a fat emulsion (Intralipid) protects the vein against infusion thrombophlebitis caused by an amino acid solution (Aminosol) was controlled by an experimental method based on a quantitative histological analysis of the inflammatory changes observed in the veins of rabbit ears after infusions. In a controlled blind study, sequential analysis failed to reveal any difference in the histological changes which developed after infusion of Aminosol alone and Aminosol plus Intralipid. In a second series of experiments in which Intralipid was compared with 0.9% NaCl it was demonstrated that the fat emulsion alone gave rise to considerable inflammatory changes in the veins.

• Authors: I Hessov, M Bojsen-Møller, F Melsen
• Journal: Intensive care medicine (Intensive Care Med) Vol. 4 Issue 3 Pg. 155-7 (Jul 1978) ISSN: 0342-4642 [Print] United States
• PMID: 690324 (Publication Type: Journal Article)

Chemical References

• Fat Emulsions, Intravenous

Topics

• Animals
• Fat Emulsions, Intravenous (therapeutic use)
• Infusions, Parenteral (adverse effects)
• Rabbits
• Thrombophlebitis (etiology, prevention & control)