[Levels of plasma 1,25-dihydroxyvitamin D and parameters of phospho-calcium metabolism in children with non-dialyzed chronic renal failure].
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| Abstract |
1,25-diOH vitamin D, 25-OH vitamin D, parathyroid hormone, calcium and phosphorus were measured in the blood of 34 children and correlated. These children, 3 months to 17 years old, had chronic renal insufficiency of varying intensity. 15 of them were treated with vitamin D. We found a negative correlation between the 1,25-diOHD levels and the reduction of the clearance of inuline, serum creatinine and uremia. This suggests a defect in 1,25-diOHD synthesis appearing when the glomerular filtration rate is decreased by about 50%, except in the case of tubulopathies, where it appears earlier. In these children, the 1,25-diOHD levels correlated with calcemia, but not with phosphoremia. The high levels of PTH were related with the lowest levels of 1,25-diOHD. The regulation of calcemia is thus basically controlled by the renal possibilities. There was a positive correlation between 1,25-diOHD and 25OHD levels when GFR was lower than 0.6 ml/sec./1,73 m2, indicating a dependence of 1,25-diOHD levels or its substrate in severe chronic renal failure.
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| Authors | B Loras, B Parchoux, F Durr |
| Journal | Archives francaises de pediatrie (Arch Fr Pediatr) Vol. 39 Suppl 2 Pg. 755-60 (Dec 1982) ISSN: 0003-9764 [Print] France |
| Vernacular Title | Taux de 1,25-dihydroxyvitamine D plasmatique et paramètres du métabolisme phosphocalcique de l'enfant en insuffisance rénale chronique non dialysé. |
| PMID | 6897703 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't) |
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