Abstract |
We have developed an in vitro haemoperfusion circuit, which closely simulates the conditions encountered in a clinical haemoperfusion, for testing the blood compatibility of new adsorbent materials. Fresh heparinised human blood is perfused for 2 hours over two model columns arranged in parallel closed circuits. The present study was performed to investigate the blood compatibility of human serum albumin-coated Amberlite XAD-7 resin. Mean platelet losses over 2 hours were greater following perfusion of the uncoated resin (44 +/- SE 5.6%) than the albumin-coated resin (17 +/- SE 2.2%) (p less than 0.01). Mean white cell losses were similar (55%) for both resins. No rises in Swank screen filtration pressure, which detects the presence of cellular aggregates in blood, were observed. Coating of XAD-7 resin with HSA therefore improves its blood compatibility with respect to platelet losses and we thus intend to use this preparation in a clinical trial of resin haemoperfusion in fulminant hepatic failure.
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Authors | R D Hughes, H Y Ton, P G Langley, D B Silk, R Williams |
Journal | The International journal of artificial organs
(Int J Artif Organs)
Vol. 1
Issue 3
Pg. 129-34
(May 1978)
ISSN: 0391-3988 [Print] United States |
PMID | 689755
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Acrylic Resins
- Biocompatible Materials
- Polystyrenes
- Serum Albumin
- amberlite XAD 7
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Topics |
- Acrylic Resins
(adverse effects)
- Biocompatible Materials
- Blood Cells
(drug effects)
- Blood Platelets
(drug effects)
- Evaluation Studies as Topic
- Hemoperfusion
- Humans
- In Vitro Techniques
- Leukocytes
(drug effects)
- Polystyrenes
- Serum Albumin
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