Abstract |
The effect of different single doses of beta-blockers cordanum ( talinolol) and obsidan was comparatively studied in 10 patients with angina pectoris of effort. The pharmacodynamic study was performed according to an original technique consisting in a sequence of monitored repeated identical treadmill exercise. The effect of the drug was evaluated by the reduction in ST-segment depression during exercise. Hemodynamic effect of cordanum was 1.7 lower than that of obsidan. The reduction of ST-segment depression effected by cordanum was 2.6 lower than in case of the corresponding doses of obsidan. The effect did not correlate with the heart rate and the double product; it terminated within 4--5 hrs.
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Authors | S A Nikolenko, V A Nazarenko |
Journal | Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR
(Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR)
Vol. 4
Issue 2
Pg. 93-100
( 1981)
ISSN: 0201-7369 [Print] Russia (Federation) |
Vernacular Title | Sravnitel'noe farmakodinamicheskoe izuchenie kordanuma i obzidana u bol'nykh stenokardieĭ napriazheniia. |
PMID | 6895599
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Propanolamines
- talinolol
- Propranolol
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Topics |
- Adult
- Angina Pectoris
(drug therapy)
- Drug Evaluation
- Exercise Test
- Hemodynamics
(drug effects)
- Humans
- Male
- Propanolamines
(therapeutic use)
- Propranolol
(therapeutic use)
- Time Factors
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