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[Comparative pharmacodynamic study of Cordanum and obzidan in stress angina pectoris patients].

Abstract
The effect of different single doses of beta-blockers cordanum (talinolol) and obsidan was comparatively studied in 10 patients with angina pectoris of effort. The pharmacodynamic study was performed according to an original technique consisting in a sequence of monitored repeated identical treadmill exercise. The effect of the drug was evaluated by the reduction in ST-segment depression during exercise. Hemodynamic effect of cordanum was 1.7 lower than that of obsidan. The reduction of ST-segment depression effected by cordanum was 2.6 lower than in case of the corresponding doses of obsidan. The effect did not correlate with the heart rate and the double product; it terminated within 4--5 hrs.
AuthorsS A Nikolenko, V A Nazarenko
JournalBiulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR (Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR) Vol. 4 Issue 2 Pg. 93-100 ( 1981) ISSN: 0201-7369 [Print] Russia (Federation)
Vernacular TitleSravnitel'noe farmakodinamicheskoe izuchenie kordanuma i obzidana u bol'nykh stenokardieĭ napriazheniia.
PMID6895599 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Propanolamines
  • talinolol
  • Propranolol
Topics
  • Adult
  • Angina Pectoris (drug therapy)
  • Drug Evaluation
  • Exercise Test
  • Hemodynamics (drug effects)
  • Humans
  • Male
  • Propanolamines (therapeutic use)
  • Propranolol (therapeutic use)
  • Time Factors

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