Selective anti-aggressive properties of DU 27725: ethological analyses of intermale and territorial aggression in the male rat.

Abstract

The effects of a new anti-aggressive compound, DU 27725, were evaluated in intermale and territorial aggression. Ethological analysis of intermale aggression showed that DU 27725 (1 to 8 mg/kg IP) strongly decreased aggression, while introductory social behaviour was unaffected or enhanced. The offensive character of aggression disappeared and was replaced by a more defensive pattern. No drastic changes occurred in non-social activities. Sedation, muscle relaxation and motor impairment did not occur at any of the doses tested, suggesting that the anti-aggressive effects were not caused by nonspecific actions of the drug. In territorial aggression, DU 27725 (4 and 8 mg/kg IP) also decreased all aspects of aggression; introductory social behaviour was slightly decreased, and defensive behaviour remained unaffected. At the highest dose (8 mg/kg) sedation was observed. DU 27725 reduced both the number of ultrasonic vocalizations and the number of bites inflicted upon the partners.

• Authors: B Olivier
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 14 Suppl 1 Pg. 61-77 ( 1981) ISSN: 0091-3057 [Print] United States
• PMID: 6894643 (Publication Type: Journal Article)

Chemical References

• Piperazines
• DU 27725

Topics

• Aggression (drug effects)
• Animals
• Dose-Response Relationship, Drug
• Humans
• Male
• Piperazines (pharmacology)
• Rats
• Territoriality