Abstract |
It has been suggested that reversal of stress-induced tachycardia by beta- adrenergic blockade might be of benefit in the treatment of phobias. This was tested in a double-blind cross-over trial by exposing 22 female volunteers with spider or snake phobias to their phobic object 1 1/2 hours after administration of either tolamolol 200 mg, diazepam 10 mg or placebo. Although tolamolol abolished the stress-induced tachycardia, it had no beneficial behavioural or subjective effects. In contrast, diazepam, which had no significant effect on heart rate, improved behavioural performance. Subjective measures were more influenced by order effect than by medication.
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Authors | M W Bernadt, T Silverstone, W Singleton |
Journal | The British journal of psychiatry : the journal of mental science
(Br J Psychiatry)
Vol. 137
Pg. 452-7
(Nov 1980)
ISSN: 0007-1250 [Print] England |
PMID | 6894099
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Placebos
- Propanolamines
- tolamolol
- Diazepam
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Topics |
- Adult
- Animals
- Diazepam
(therapeutic use)
- Fear
(drug effects)
- Female
- Heart Rate
(drug effects)
- Humans
- Male
- Mice
- Phobic Disorders
(drug therapy)
- Placebos
- Propanolamines
(therapeutic use)
- Snakes
- Spiders
- Tachycardia
(drug therapy)
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