HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Behavioural and subjective effects of beta-adrenergic blockade in phobic subjects.

Abstract
It has been suggested that reversal of stress-induced tachycardia by beta-adrenergic blockade might be of benefit in the treatment of phobias. This was tested in a double-blind cross-over trial by exposing 22 female volunteers with spider or snake phobias to their phobic object 1 1/2 hours after administration of either tolamolol 200 mg, diazepam 10 mg or placebo. Although tolamolol abolished the stress-induced tachycardia, it had no beneficial behavioural or subjective effects. In contrast, diazepam, which had no significant effect on heart rate, improved behavioural performance. Subjective measures were more influenced by order effect than by medication.
AuthorsM W Bernadt, T Silverstone, W Singleton
JournalThe British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 137 Pg. 452-7 (Nov 1980) ISSN: 0007-1250 [Print] England
PMID6894099 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Placebos
  • Propanolamines
  • tolamolol
  • Diazepam
Topics
  • Adult
  • Animals
  • Diazepam (therapeutic use)
  • Fear (drug effects)
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Mice
  • Phobic Disorders (drug therapy)
  • Placebos
  • Propanolamines (therapeutic use)
  • Snakes
  • Spiders
  • Tachycardia (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: