[Investigations on the percutaneous activity of a combination of heparin, allantoin and dexpanthenol in a specific ointment base, Antiinflammatory effect on UV-erythema in the guinea pig].

Abstract

Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation. After a pretreatment of 30 min, the temperature of the erythematous skin is also significantly lower. At a pretreatment of 120 min, no temperature differences can be observed between the ointment groups. This effect might result from a superimposition of the anti-erythematous/antiinflammatory effect of Hepathrombin along with a vasodilation effect on the deeper skin layers. The antiinflammatory effect of Hepathrombin is also discussed in connection with the mechanism of UV-induced erythema. The inhibition of UV-erythema by Hepathrombin underlines the rapid skin penetration of the active substances.

• Authors: H D Tauschel, C Rudolph
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 32 Issue 9 Pg. 1096-100 ( 1982) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Untersuchungen zur perkutanen Wirksamkeit einer Heparin-Allantoin-Dexpanthenol-Kombination in spezieller Salbengrundlage. Antiinflammatorische Wirkung auf UV-Erytheme am Meerschweinchen.
• PMID: 6890833 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Drug Combinations
• Pantothenic Acid
• Allantoin
• Ulcrux
• Heparin

Topics

• Allantoin (pharmacology)
• Animals
• Anti-Inflammatory Agents
• Drug Combinations (pharmacology)
• Erythema (drug therapy)
• Guinea Pigs
• Heparin (pharmacology)
• Male
• Pantothenic Acid (analogs & derivatives, pharmacology)
• Skin Temperature (drug effects)
• Time Factors
• Ultraviolet Rays